Nexus Biosystems LINKbrooks LINKnexus

Economics of Miniaturization

Increased throughput can lead to increased cost. Miniaturizing assays using high density microplates permits greater throughput with very significant reduction in reagent consumption and therefore costs and time.

  96 Well 384 Well 384 Well LV 1536 Well 3456 Well
Total well volume used (μL per well) 200 50 20 7 2
Compound or other special material (vol. in nL) 100 25 10 4 1
Special material cost $10.00
$2.50 $1.00 $0.40 $0.10
Reagent cost $0.20
$0.05 $0.02 $0.01 $0.00
Sample Cost = Reagent + Special $10.20
$2.55 $1.02 $0.41 $0.10
Sample Cost per Plate $979.20
$979.20 $391.68 $625.15 $352.51
Sample Cost per Screen $10,200,000
$2,550,000 $1,020,000 $407,000 $102,000
Sample Cost per Year $153,000,000 $38,250,000 $15,300,000 $6,105,000 $1,530,000
 
No. Plates 156,250 39,063 39,062.5 9,766 4,340
Plate Pricing $5.00 $8.00 $10.00 $25.00 $40.00
Yearly Plate Cost $781,250 $312,500 $390,625 $244,141 $173,611
 
Totally Screening Consumable Cost $153,781,250 $38,562,500 $15,690,625 $6.349.141 $1,703,611
Total Wells 15,000,000 15,000,000 15,000,000 15,000,000 15,000,000
 
Cost per Well $10.25 $2.57 $1.05 $0.42 $0.11